Fenbendazole

Fenbendazole

Fenbendazole

Fenbendazole: A Groundbreaking Alternative Cancer Treatment

Exploring the Power of FenBen in Cancer Therapy

Fenbendazole, often referred to as FenBen, is an anthelminthic medication initially developed to eliminate roundworms and pinworms in animals and humans. Although first introduced in 1961, it wasn't until 2002 that FenBen's potential as a cancer treatment was fortuitously discovered during a glioblastoma study at Johns Hopkins University. In the study, FenBen outperformed Mebendazole in GBM trials. Since then, numerous case reports have demonstrated FenBen's effectiveness in treating various cancers, including lung, kidney, liver, breast, prostate, melanoma, bone, ovary, colon, and brain tumors.

Understanding the Mechanism of Fenbendazole in Cancer Treatment

  1. Induction of apoptosis: Fenbendazole interacts with β-tubulin, leading to cell cycle arrest and cytotoxicity. This interaction inhibits the polymerization of tubulin into microtubules in both helminths and human tumor cells.
  2. Inhibition of glucose uptake in cancer cells: Cancer cells have high glucose uptake, which can be seen in PET scans. Fenbendazole limits glucose uptake in cancer cells by decreasing the amount of GLUT transporters and the enzyme hexokinase, which helps tumors thrive.
  3. Reactivation of the p53 gene: Though still controversial, growing evidence suggests fenbendazole may increase the p53 gene, the most potent tumor suppressor in our bodies.

Fenbendazole possesses unique characteristics that make it an exceptional anti-cancer strategy. Notably, cancer cells do not develop resistance to fenbendazole, as it is not a target for P-glycoproteins, the excretory drug efflux pumps. Furthermore, fenbendazole can sensitize tumors to radiotherapy, similarly to chemotherapy agents from the taxane group.

FenBen's primary mechanism of action involves disrupting the microtubule system within cancer cells. Microtubules play a crucial role in cell division, and by targeting this system, FenBen effectively inhibits cancer cell growth. The drug also blocks glucose utilization, which is essential for cancer cells to survive and proliferate.

Additionally, FenBen helps upregulate P53 tumor suppressor genes, further enhancing its anti-cancer properties. It prevents the formation of new blood vessels that supply tumors with essential nutrients, effectively starving cancerous growths. Remarkably, FenBen selectively targets cancer cells while sparing healthy ones. This selectivity, combined with minimal reported side effects, makes FenBen a promising alternative cancer treatment.

Key Considerations for FenBen Usage

While FenBen's potential in cancer treatment is evident, its current licensing for animal use only means oncologists cannot prescribe it for human cancer patients.

Progressive Research and Future Outlook

FenBen has shown promising results in studies involving glioblastoma multiforme (GBM), non-small cell lung cancer (NSCLC), lymphoma, metastatic colorectal cancer, and prostate cancer. Researchers are actively investigating its potential as a viable alternative cancer treatment. As more studies emerge, the medical community may acknowledge FenBen's potential and work towards its approval for human cancer therapy.

Fenbendazole Safety & Side Effects

Fenbendazole belongs to the benzimidazole class of drugs, which also includes Mebendazole and Albendazole. These drugs have been deemed safe based on toxicology studies. However, no drug is without potential side effects. Although significant adverse reactions have not been widely reported with fenbendazole, some anecdotal evidence suggests the following:

• Approximately 5 % of users may experience stomach discomfort or diarrhea when taking large doses of fenbendazole without breaks.

• Individuals with severe liver or kidney failure may have lower rates of medication excretion, leading to accumulation of fenbendazole and potential side effects. In these cases, it is recommended to divide doses appropriately.

• Prolonged use of large doses of fenbendazole can cause an asymptomatic increase in liver enzymes, as the substance is primarily metabolized in the liver. This increase is reversible with a brief pause from the medication.

To maintain optimal liver health, it is suggested to take a break from fenbendazole at least once a week if the medication is used for extended periods (months or years). Additionally, taking daily supplements of 250 mg of Milk Thistle or 150 mg of Silymarin can support liver health.

In conclusion, Fenbendazole's serendipitous discovery as a cancer treatment has paved the way for a novel and promising approach in combating various forms of cancer. With continued research and increased awareness, this drug may soon become an essential part of the oncologist's arsenal, offering hope to millions of cancer patients worldwide.

References

  1. https://www.nature.com/articles/s41598-018-30158-6
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436308/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/
  4. https://apps.dtic.mil/dtic/tr/fulltext/u2/a545657.pdf
  5. https://www.ncbi.nlm.nih.gov/pubmed/21764822
  6. https://www.ncbi.nlm.nih.gov/pubmed/2009737
  7. https://pubmed.ncbi.nlm.nih.gov/22048645/
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769799/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/
  10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158014/
  11. https://pubmed.ncbi.nlm.nih.gov/4082261/
  12. https://www.mycancerstory.rocks/single-post/2016/08/22/Shake-up-your-life-how-to-change-your-own-perspective
  13. https://www.researchgate.net/publication/260343692_Effects_of_fenbendazole_and_vitamin_E_succinate_on_the_growth_and_survival_of_prostate_cancer_cells
  14. https://www.hopkinsmedicine.org/news/publications/doorways_to_discovery/doorways_to_discovery_2015/surprise_finding_yields_a_possible_tumor_fighting_drugI

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