BCF Ketone Metabolic Therapy Education
Ketone Metabolic Therapy (KMT)
This education is a metabolic cancer approach to treating cancer and treatment plan that combines ketone metabolic therapy (KMT), vitamins, certain repurposed drugs, and other therapies. The goal is to boost healthy cells’ energy production while causing cancer cells to die. In cancer cells, this mix creates a reaction that leads to cell death. This treatment also targets the energy sources cancer cells use, as well as specific immune cells called macrophages, which play a role in cancer spread.
There are other repurposed drugs that can be repurposed to target mitochondria, like Metformin, which is used for OxPhos, and Doxycycline, which can promote mitochondrial growth. Other vitamins and supplements that might be used include vitamin K2, vitamin E, coenzyme Q10, methylene blue, niacinamide, riboflavin, Artemisinin, melatonin, NADH, magnesium and others.
Cancer cells need two main energy sources, glucose and glutamine, to survive and grow because their energy-making process (OxPhos) doesn’t work properly. The environment around the tumor (which results from damaged mitochondria) has several characteristics, including high acidity, low oxygen, increased pressure, heat, and changes in the water inside cells. It also has weakened electric activity.
Fasting & Interment Fasting
Fasting helps improve how well our cells produce energy (through a process called OxPhos) and activates a natural cleaning process in our body (autophagy). It also reduces the use of sugar and another nutrient (glutamine) that cancer cells rely on. Fasting not only encourages the growth of healthy stem cells but can also affect cancer stem cells (CSCs) through autophagy. Cutting off glucose (sugar) can lead to the death of these cancer stem cells. In studies, fasting has shown anti-cancer effects and can boost the effectiveness of certain treatments. Experts now believe fasting should become a recognized part of cancer treatment.
Ketogenic Diet and Ketone Metabolic Therapy (KMT)
The ketogenic (keto) diet, along with fasting, may limit the nutrients cancer cells need (glucose and glutamine) while boosting the body's energy production (OxPhos).
Therapeutic ketosis—through the keto diet or ketone supplements—can slow cancer stem cell growth, promote cell death (apoptosis), and improve how cells breathe (cellular respiration). The keto diet has shown to have anti-cancer effects both in lab studies and in animals by disrupting the way cancer cells get energy (via glycolysis).
Maximum benefit from reducing glutamine (another fuel for cancer cells) and taking a drug called fenbendazole comes when these are paired with a strict keto diet.
The goal of the ketogenic diet and KMT is to block the pathways cancer cells use for energy (glycolysis and glutaminolysis) while shifting the body into ketosis to target both cancer stem cells and other cancer cells. Ketone supplements may also help to fight tumors by stopping cancer spread and attacking key features of cancer growth.
For All Cancer Stages:
A ketogenic diet involves eating low carbohydrates and high fat, with meals totaling 900 to 1,500 calories a day.
Ketone metabolic therapy usually includes:
• 60-80% of calories from fat
• 15-25% from protein
• 5-10% from fibrous carbs.
It's important to stay well-hydrated and eat simple, whole foods while following this diet. A key goal is to reach a glucose ketone index (GKI) score of 2.0 or lower, which you can check 2-3 hours after meals, ideally twice a day.
The Mitochondrial-Stem Cell Connection
There is also a mitochondrial-stem cell connection (MSCC) theory suggests that cancer starts when stem cells in the body can’t produce energy properly. This energy problem leads to the creation of cancer stem cells (CSCs) and causes abnormal energy use in the cells, eventually leading to cancer. This idea brings together two important concepts: the cancer stem cell theory and the metabolic theory of cancer.
Based on research in biology, medicine, and clinical studies, this paper introduces a treatment approach that targets the MSCC. It includes several recommendations, involving specific natural molecules, repurposed drugs, and other therapies. The goal is to improve the way cells produce energy, stop cancer cells from using their main fuels (glucose and glutamine), and prevent the spread of cancer (metastasis). Many experiments suggest that focusing on MSCC could be a promising way to treat cancer.
In summary, the MSCC might play a key role in cancer treatment. Based on current knowledge, we propose using specific natural molecules, drugs, and therapies to help restore normal energy production in cells, target cancer stem cells, and stop cancer cells from using glucose and glutamine for energy. This approach also aims to address the spread of cancer by targeting cancer stem cells that have fused with immune cells called macrophages. Research on cells, animals, and humans supports the idea that targeting the MSCC could help both prevent and treat cancer.
Repurposed Drugs: A New Dawn in Cancer Treatment
Several drugs, initially not designed for cancer treatment, surprisingly show promising anti-cancer properties. These benefits might include cutting blood sugar levels, reducing inflammation, lowering platelets, and, importantly, possessing the potential to attack and kill cancer cells. Such repurposed drugs may offer compelling advantages in terms of safety and cost-effectiveness compared to new drug development.
However, it's essential to judiciously choose the right compounds to construct an anti-cancer program that considers each individual's unique needs and condition.
Evidence-Based Functional Medicine: The Underpinning Philosophy
At the core of this approach lies the philosophy of functional medicine, as aptly stated by Dr. Henry Friedman, "It is naive to believe you can treat a cancer with one drug." Functional medicine underscores the principle of treating the person as a whole, aiming to create a body conducive to health rather than merely eradicating the disease.
Hence, as Hippocrates said, “healing people starts in the gut, because that's where illness starts”. We also believe health is driven outwards from the gut microbiome.
Your microbiome and your gut lining control 85 percent of your immune response. 85 percent of immune cells being present in the gut, there is an intricate interplay between the intestinal microbiota, the intestinal epithelial layer, and the local mucosal immune system. Do you want to diminish your gut it when you are trying to fight cancer?
“Should you be diagnosed with cancer, it indicates your body has inadvertently become a hospitable environment for the disease. Our objective is to assist you in restructuring your body into a fortress of health, creating an environment where cancer struggles to thrive.”
Beat Cancer Foundation uses a mixture of Enhancing and Repairing the immune system, Diet, Exercise, Supplements, Herbs, Repurpose Drugs, and Detoxing. Please understand you can help fight your cancer, alongside or instead of conventional treatments. See our Elite Eleven Approach:
Purposes for the Elite Eleven Approach & Customizing Treatment Strategies
Recognizing that every individual and their cancer are unique, we advocate for tailored treatment approach.
1. Intake & Assessment
To build a health-promoting environment, we need a thorough understanding of your current health status. This first stage involves meticulous collection and analysis of your health data.
2. Repairing the Immune System
Central to this journey is the restoration of the immune system, focusing mainly on gut health. By creating an optimal environment in your gut, we're empowering your body's natural defense system.
3. Alkalizing Diets
We propose diets that create an alkaline environment hostile to cancer. These diets offer the necessary nutritional support while also starving the cancer cells.
4. Non-toxic Treatment Evaluation
We closely evaluate non-toxic treatments to identify those with the best potential to bolster your cancer-fighting regimen without debilitating side effects.
5. Repurposed Drugs
Many non-cancer drugs show promising anti-cancer potential. For example, Fenbendazole has exhibited promising results in cancer research. It has been studied for its effectiveness against cancers like GBM, NSCLC, lymphoma, metastatic colorectal cancer, and prostate cancer.
6. Alternative Therapies
We also explore a range of alternative therapies that might be complementary to your treatment regimen.
7. Complementary Supplements
The BCF program highlights a spectrum of natural compounds, from herbs to supplements, that are known to inhibit cancer growth, and some even enhancing the efficacy of conventional treatments. These include but are not limited to Berberine, Resveratrol, EGCG, Turmeric, Sulforaphane, Genistein, Ursolic acid, Piperine, and Feverfew.
8. Exercise
Exercise is crucial for individuals battling cancer as it triggers the release of myokines, proteins that aid the immune system in combating and even eradicating cancer cells. Incorporating moderate activities like walking and strength training can counteract the muscle loss that frequently occurs during cancer treatment and recovery.
9. Eliminating Cancer Stem Cells
Aiming to reduce the stubborn cancer stem cells that evade standard care, we rely on drugs like Doxycycline or natural compounds that target these elusive cells.
10. Detoxification
Detoxing, a pivotal step in the program, aims to purge the body of harmful toxins that can exacerbate cancer or hamper its treatment.
11. Preventing Cancer Recurrence
Our final objective is to arm your body against recurrence, enabling it to maintain the balance achieved through the program.
By understanding these repurposed drugs and their potential benefits, patients and practitioners can tap into a powerful arsenal in the battle against cancer. Harnessing these underutilized resources could revolutionize cancer treatment and survival rates, helping us make significant strides toward a future free of cancer.
Providing assistance in establishing a repurposed drug program
1. For accessing these repurposed drugs, you may need to find an online group of prescribers. Additionally, you could consider incorporating natural compounds like berberine and lycopene that work similarly to some of the mentioned drugs, or drugs like Metformin and Atorvastatin that could potentially have anti-cancer benefits.
2. Cancer uses histamines to form tumors and spread. Anti-histamines like cimetidine, desloratadine, and loratadine have been shown to increase survival times in cases of colorectal and breast cancer.
3. Beta-blockers like propranolol have shown promise in increasing survival times for a range of cancers, including ovarian, colorectal, breast, pancreatic, stomach, prostate, leukemia, angiosarcoma, and lung cancer.
4. Also, you might want to explore natural compounds known to correct cancer stem cells like vitamin D3, feverfew, ursolic acid, EGCG, genistein, lycopene, curcumin, resveratrol, ashwagandha, and delphinidin.
5. Some additional off-label drugs to consider include Low Dose Naltrexone, or LDN, which can boost the immune system and provide some pain relief, and drugs like Celebrex, which has a unique dual-action approach against cancer.
Let’s start to build a body conducive to health and beating cancer. If repurpose drugs can help you, you should use them.
Here are some examples of repurposed drugs and their specific applications in cancer treatments
When considering alternative strategies for cancer treatment, the utilization of existing drugs, known as drug repurposing, has shown promising results. A number of medications developed for other conditions have revealed anti-cancer properties.
Accutane: was originally developed for severe acne, Accutane has shown positive effects against GBM, neuroblastoma, and breast cancer, particularly when combined with Metformin. It targets cancer stem cells and has been utilized as anti-cancer chemotherapy in the United States. It's effective against:
· GBM - Aids in preventing recurrence of brain tumors
· Neuroblastoma
· Breast cancer (when used with metformin)
· Skin cancer
Note: Accutane has strong side effects, so use cautiously.
Accutane (Isotretinoin & Retinol):
a)https://www.cancer.gov/research/participate/clinical-trials/intervention/isotretinoin
b) https://pubmed.ncbi.nlm.nih.gov/25520935/
c) https://pubmed.ncbi.nlm.nih.gov/26035122/
d) https://pubmed.ncbi.nlm.nih.gov/25543955/
e) https://pubmed.ncbi.nlm.nih.gov/28754309/
f) https://pubmed.ncbi.nlm.nih.gov/21073338/
g) https://chemocare.com/chemotherapy/drug-info/accutane.aspx
Atorvastatin: this statin reduces blood fat levels and may slow metastasis. Research suggests that people with high blood fat levels have a higher incidence of metastases. Atorvastatin might inhibit cancer spread and improve survival times by reducing these fats.
Atorvastatin:
a) https://pubmed.ncbi.nlm.nih.gov/16939047/
b) https://www.ncbi.nlm.nih.gov/pubmed/28075470
c) https://www.ncbi.nlm.nih.gov/pubmed/28769006
d) https://www.ncbi.nlm.nih.gov/pubmed/22531631
e) https://www.ncbi.nlm.nih.gov/pubmed/27441003
f) https://pubmed.ncbi.nlm.nih.gov/29763460/
g) https://pubmed.ncbi.nlm.nih.gov/32662332/
h) https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0209486
i) https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-1066-z
j) https://www.cancercenter.com/community/blog/2021/03/statins-and-cancer
Berberine: this potent herb has immense potential in the fight against cancer. It regulates blood sugar, corrects cancer cell mitochondria, and exhibits anti-microbial and anti-inflammatory properties. It also acts as a chemosensitizer. Berberine has demonstrated positive effects on the following cancer types:
· Colorectal cancer
· Lung cancer
· Ovarian cancer
· Prostate cancer
· Liver cancer
· Cervical cancer
Berberine:
a) https://pubmed.ncbi.nlm.nih.gov/34885950/
b) https://pubmed.ncbi.nlm.nih.gov/23974852/
c) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382680/
d) https://pubmed.ncbi.nlm.nih.gov/25153862/
e) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271598/
f) https://www.sciencedirect.com/science/article/abs/pii/S0378874115301872?via%3Dihub
Celebrex: this anti-inflammatory drug has a dual-action approach against cancer: it triggers self-destruction of cancer cells and sensitizes them to chemotherapy. It's effective against:
· Prostate cancer
· Lung cancer
· Breast cancer
· Colorectal cancer
· Brain cancer
Celecoxib in Cancer Therapy and Prevention:
a) https://pubmed.ncbi.nlm.nih.gov/30073924/
b) https://www.cancer.gov/research/participate/clinical-trials/intervention/celecoxib
Cimetidine: an antacid antihistamine that shows promise against various types of cancer and may increase survival times in certain cancers such as:
· Colorectal cancer
· Gastric cancer
· Melanoma
· Kidney cancer
Cimetidine:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268104/
b) https://pubmed.ncbi.nlm.nih.gov/11870500/
c) https://pubmed.ncbi.nlm.nih.gov/7736883/
d) https://pubmed.ncbi.nlm.nih.gov/21329756/
Clemastine: an antihistamine that can help reverse brain fog and myeloid damage.
Clemastine:
a) https://pubmed.ncbi.nlm.nih.gov/35007691/
b) https://www.mdpi.com/2072-6694/15/18/4619
c) https://www.biorxiv.org/content/10.1101/2022.11.05.515291v2.full.pdf
Colloidal Silver/MesoSilver: lab experiments suggest these particles, when used alone or combined with conventional therapies like chemotherapy and radiotherapy, could potentially combat most types of cancer, both directly and indirectly.
Silver nanoparticles have been found effective against most types of cancer. Their mechanisms include triggering apoptosis, inhibiting angiogenesis, disrupting autophagy, killing intratumoral bacteria, and enhancing the efficacy of chemotherapy and radiotherapy.
Colloidal Silver/MesoSilver:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777983/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965924/
c) https://pubmed.ncbi.nlm.nih.gov/30483817/
d) https://pubmed.ncbi.nlm.nih.gov/27574420/
e) https://www.mdpi.com/2079-4991/11/4/964
f) https://pubmed.ncbi.nlm.nih.gov/29435134/
g) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797005/
h) https://pubmed.ncbi.nlm.nih.gov/28919753/
i) https://pubmed.ncbi.nlm.nih.gov/27536105/
j) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558162/
k) https://pubmed.ncbi.nlm.nih.gov/26867977/
l) https://pubmed.ncbi.nlm.nih.gov/19508889/
Desloratadine and Loratadine: is an oral antihistamine with a unique anti-cancer benefit for breast cancer. Research from the Karolinska Institute suggests that antihistamines, used one week after surgery, can restrict loose cancer cells from causing secondary infections and may significantly improve survival rates.
· Breast cancer
Desloratadine and Loratadine:
a) https://pubmed.ncbi.nlm.nih.gov/33550204/
b) https://jeccr.biomedcentral.com/articles/10.1186/s13046-023-02914-8
Dichloroacetate (DCA): an unpatented drug primarily used for metabolic disorders, DCA has shown potential in treating glioblastoma multiforme and other cancers by altering their metabolism.
· Brain cancer
· Glioblastoma (GBM)
Dichloroacetate (DCA):
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885244/
b) https://esmed.org/MRA/mra/article/view/4118
c) https://ccnm.edu/sites/default/files/2023-06/DCA-patient-resource-July-22-2022.pdf
Dipyridamole: is known for treating heart disease, Dipyridamole reduces platelets and inflammation, thereby inhibiting cancer growth, and it's effective against:
· Melanoma
· Colorectal cancer
· Breast cancer
· TNBC (especially when combined with the antihistamine cimetidine)
Dipyridamole:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882894/
b) https://pubmed.ncbi.nlm.nih.gov/36939950/
Disulfiram: is primarily used in the treatment of chronic alcoholism, Disulfiram has shown promising results against various cancers, including breast and liver cancer, due to its ability to induce cancer cell death. Research shows it seems to be more effective if used in conjunction with thiamine (vitamin B1) and caffeinated tea. It's effective against:
· Breast cancer
· Prostate cancer
· Ovarian cancer
· Pancreatic cancer
Disulfiram:
a) https://pubmed.ncbi.nlm.nih.gov/31084595/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161604/
c) https://www.frontiersin.org/articles/10.3389/fmolb.2021.741316/full
Doxycycline & IV Vitamin C: research indicates this combination disrupts cancer stem cells' energy production and convert them into normal cells. Cancer Stem cells are the primary reason why cancer returns and there is NO current conventional cancer drug available to deal with them. We also recommend (Berberine and Ivermectin) to finish the job off.
Doxycycline & IV Vitamin C:
a) https://pubmed.ncbi.nlm.nih.gov/31002656/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620172/
c) https://pubmed.ncbi.nlm.nih.gov/25625193/
d) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801417/
e) https://pubmed.ncbi.nlm.nih.gov/28039467/
Fenbendazole: is an anti-helminthic drug commonly used for treating pinworm infestations in animals and blocks tubulin. This drug interacts with β-tubulin, leading to cell cycle arrest and cytotoxicity. It can limit glucose uptake in cancer cells, thereby inhibiting tumor growth. It interacts with β-tubulin, leading to cell cycle arrest and cytotoxicity, thereby limiting glucose uptake in cancer cells and potentially increasing the p53 gene, a potent tumor suppressor. It's effective against:
· GBM
· NSCLC
· Lymphoma
· Metastatic colorectal cancer
· Prostate cancer
· Lung cancer
· Osteosarcoma
Fenbendazole:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/
b) https://pubmed.ncbi.nlm.nih.gov/22048645/
c) https://www.nature.com/articles/s41598-018-30158-6
d) https://pubmed.ncbi.nlm.nih.gov/21764822/
e) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436308/
f) https://pubmed.ncbi.nlm.nih.gov/4082261/
Fluvastatin: like other statins, is generally used to control high cholesterol levels. It can also be useful in cancer care due to its ability to reduce cancer growth, progression, and metastasis. It works by reducing inflammation, suppressing blood supply formation for tumors, and reducing cancer cell proliferation. It's effective against:
· Breast cancer
· Colorectal cancer
· Prostate cancer
Fluvastatin:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760927/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087110/
Itraconazole: is an antifungal medication, is known to lower chemotherapy resistance, increase survival times, and target mTOR and AMPK, two drivers of cancer. It's effective against:
· Breast cancer
· TNBC
· Colorectal cancer
· Pancreatic cancer
· NHL
· Endometrial cancer
· NSCLC
· Prostate cancer
Itraconazole:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588108/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406527/
c) https://www.sciencedirect.com/science/article/pii/S0753332222010058
Ibuprofen: is regular use could reduce the risk of certain cancers, particularly colon cancer. This NSAID reduces inflammation, a risk factor for several types of cancer.
Ibuprofen/Aspirin:
a) https://pubmed.ncbi.nlm.nih.gov/15756426/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451865/
c) https://pubmed.ncbi.nlm.nih.gov/28292923/
d) https://pubmed.ncbi.nlm.nih.gov/28377721/
e) https://pubmed.ncbi.nlm.nih.gov/28507039/
f) https://pubmed.ncbi.nlm.nih.gov/28189429/
Ivermectin: is an anti-parasitic drug, shows promising results against cancer. Its efficacy, similar to Fenbendazole, isn't well-recognized due to licensing restrictions. Along with berberine, Ivermectin disrupts stem cell energy production and transforms cancer stem cells into less potent cells. It's effective against:
· Lymphoma
· Leukemia
· Solid tumors such as ovarian
· TNBC
· Breast cancer
Ivermectin:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/
b) https://pubmed.ncbi.nlm.nih.gov/29257278/
c) https://pubmed.ncbi.nlm.nih.gov/32549918/
d) https://pubmed.ncbi.nlm.nih.gov/29257278/
e) https://pubmed.ncbi.nlm.nih.gov/32474842/
f) https://pubmed.ncbi.nlm.nih.gov/26078298/
g) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982461/
h) https://pubmed.ncbi.nlm.nih.gov/31755894/
i) https://pubmed.ncbi.nlm.nih.gov/30596403/
j) https://pubmed.ncbi.nlm.nih.gov/27771251/
k) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/
l) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982461/
m) https://pubmed.ncbi.nlm.nih.gov/20644115/
n) https://pubmed.ncbi.nlm.nih.gov/34483925/#affiliation-1
o) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8539496/
p) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925581/
q) https://pubmed.ncbi.nlm.nih.gov/28847725/
Lycopene: is a natural compound found in tomatoes, has blood lipid-lowering benefits comparable to statins. It reduces the risk of aggressive prostate cancer and other cancers. It also acts as an antioxidant against cancer stem cells. Although slower acting, it can complement other treatments and is said to at least double life expectancy for people with cancer.
Lycopene:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741066/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832910/
Mebendazole: is an anti-helminthic drug commonly used for treating pinworm infestations in humans, blocks tubulin. Tubulin is crucial for cell division and, when blocked, can inhibit cancer cell growth. Despite its potential, we recommend Fenbendazole over Mebendazole due to better efficacy. It's effective against:
· GBM
· Lung cancer
· Osteosarcoma
Mebendazole:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954103/
Meclizine: was originally an antiemetic and antihistamine, Meclizine displays potential in halting cell division, specifically in chronic lymphocytic leukemia (CLL), by blocking DNA synthesis in cancer cells.
Meclizine:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188425/
b) https://pubmed.ncbi.nlm.nih.gov/17222494/
Melatonin: acts as a potent antioxidant and anti-inflammatory, reduces natural estrogen, and targets cancer cells in at least five different ways.
· Modifying estrogen receptors
· Inducing apoptosis (programmed cell death)
· Inhibiting metastasis (spread of cancer cells)
· Restricting angiogenesis (formation of blood supply to tumors)
· Restoring mitochondrial function
Melatonin is nearly universally effective against various types of cancer. It also functions as a chemosensitizer and radiosensitizer, making cancer cells more susceptible to anti-cancer compounds and reducing side effects from chemotherapy and radiotherapy. We recommend you take 60 mg of melatonin 45 minutes before bed.
Melatonin:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123278/
b) https://pubmed.ncbi.nlm.nih.gov/29484412/
c) https://pubmed.ncbi.nlm.nih.gov/18289162/
d) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8627858/
e) https://pubmed.ncbi.nlm.nih.gov/28801373/
f) https://cancerci.biomedcentral.com/articles/10.1186/s12935-020-01531-1
g) https://www.mdpi.com/1422-0067/23/7/3779
Metformin: is a drug used for diabetes that helps regulate blood sugar levels, also demonstrates promising effects against various cancer types. By targeting molecular pathways such as mTOR, AMPK, IGF-1, and NF-kB, Metformin may inhibit the growth of several cancers. It's effective against:
· Breast cancer
· Prostate cancer
· Lung cancer
· Colon cancer
· Esophageal cancer
· Melanoma cancer
Metformin:
a) https://pubmed.ncbi.nlm.nih.gov/30572481/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839379/
c) https://pubmed.ncbi.nlm.nih.gov/28444639/
d) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497052/
e) https://www.nature.com/articles/s41416-020-01186-9
f) https://pubmed.ncbi.nlm.nih.gov/24844651/
g) https://pubmed.ncbi.nlm.nih.gov/28769006/
h) https://pubmed.ncbi.nlm.nih.gov/30651580/
i) https://pubmed.ncbi.nlm.nih.gov/36336804/
j) https://pubmed.ncbi.nlm.nih.gov/26630530/
Metronidazole: is generally known as an antibiotic, Metronidazole has shown potential anti-cancer effects against some forms of cancer, including colorectal and gastric cancers. This is due to its ability to interfere with the DNA synthesis of cancer cells. It's effective against:
· Colorectal cancer
· Gastric cancer
Metronidazole:
a) https://pubmed.ncbi.nlm.nih.gov/29595104/
Naltrexone: Low Dose Naltrexone (LDN), used with vitamin D3 and alpha lipoic acid, can enhance the immune system, provide pain relief, and inhibit cancer growth. Increasingly used with cannabis at night and CBD or RSO by day, LDN has a dosage of 0.5 to 4.5mg, taken in pulses (3 days on, 3 days off). For breast, ovarian and similar cancers, practitioners report the best results with a ratio of 1 part THC to 4 parts CBD. For brain tumors, it is 1:1. It's effective against:
· Breast cancer
· Ovarian cancer
· Colorectal cancer
Naltrexone:
a) https://pubmed.ncbi.nlm.nih.gov/33504322/
b) https://pubmed.ncbi.nlm.nih.gov/33337537/
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): the regular use of NSAIDs has been associated with reduced risk and improved survival in various cancers.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs):
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836048/
b) https://seer.cancer.gov/archive/studies/epidemiology/study17.html
Niclosamide: is long known for treating tapeworm infections, targets cancer cells characterized by a p53 deficiency, a common condition in most cancer cells (60% of all cancer), similar to Fenbendazole. This targeted approach induces apoptosis, disrupts stem cell energy, and converts cancer stem cells to ordinary cancer cells, leading to impressive tumor size reduction. Niclosamide also inhibits cancer cell migration, metastasis, and cancer stem cells. It's effective against:
· GBM
· NSCLC
· Lymphoma
· Colorectal cancer
· Prostate cancer
· Lung cancer
· Osteosarcoma
Niclosamide:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9720275/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9782559/
Propranolol: is a non-specific Beta-blocker primarily known for treating hypertension, can counteract the metastatic aggression of tumors, believed to be stimulated by stress hormones via COX-2. By inhibiting this process, Propranolol has shown potential in reducing the aggression and metastases of various cancers. It can block VEGF, and research shows it reduces progression, increasing survival times. It's effective against:
· Lung cancer
· Colorectal cancer
· Breast cancer
· Melanoma
· Pancreatic cancer
· Prostate cancer
· Stomach cancer
· Leukemia
· Ovarian Cancer
· Angiosarcoma
Propranolol:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504645/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102691/
c) https://pubmed.ncbi.nlm.nih.gov/23300016/
d) https://www.sciencedirect.com/science/article/pii/S1044579X13000850#bib0040
Rapamycin: this immunosuppressant can potentially slow cancer growth by inhibiting the mTOR pathway, a crucial regulator of cell growth, proliferation, and survival. It could be effective against a variety of cancers, particularly renal cell carcinoma.
· Renal Cell Carcinoma
Rapamycin:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10103596/
b) https://pubmed.ncbi.nlm.nih.gov/16039868/
c) https://www.upmc.com/media/news/013119-liver-cancer-rapamycin
Simvastatin: is a drug commonly used for lowering cholesterol levels, has shown potential anti-cancer properties in some research studies. Evidence suggests that it might inhibit the growth and proliferation of various cancer cells. It's effective against:
· Breast cancer
· Colorectal cancer
· Prostate cancer
Simvastatin:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417177/
b) https://www.sciencedirect.com/science/article/pii/S0753332221006405
Sildenafil: is known for Viagra, has demonstrated anti-cancer effects by enhancing anti-tumor immunity and inhibiting the development of MDSCs (myeloid-derived suppressor cells), which are associated with tumor progression. It has shown efficacy in:
· Colorectal cancer
· Prostate cancer
Sildenafil:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234771/
b) https://pubmed.ncbi.nlm.nih.gov/29110626/
Thalidomide: has found a new role as a cancer treatment option. It's particularly used in multiple myeloma cases, acting as an immunomodulatory agent that helps to stimulate the immune system to fight cancer cells.
Thalidomide:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084783/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112512/
Tocotrienols: these members of the Vitamin E family have demonstrated anti-cancer effects in preclinical models. They can potentially inhibit cancer cell growth and induce apoptosis. It has shown efficacy in:
· Breast cancer
· Pancreatic cancer
· Skin cancer
Tocotrienols:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359475/
b) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386883/
c) https://www.mdpi.com/2076-3921/10/9/1383
Verapamil: is used to treat high blood pressure, angina, and arrhythmia, this calcium channel blocker can potentially inhibit the growth of cancer cells, particularly those resistant to chemotherapy, by preventing the efflux of chemotherapeutic agents from cancer cells. It may be beneficial in treating various cancers, including:
· Breast cancer
· Ovarian cancer
· Lung cancer
Verapamil:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902079/
Zoledronic Acid: is used to treat osteoporosis and high blood calcium levels (hypercalcemia), Zoledronic acid has shown potential as an adjuvant therapy in reducing the recurrence of cancer and other solid tumors. It has shown to be more effective at preventing or delaying complications such as bone fractures, compression of the spinal cord, and severe bone pain than Pamidronate. It may be beneficial in treating various cancers, including:
· Osteoporosis
· Bone metastases
· Breast cancer
· Lung cancer
· Multiple myeloma
Zoledronic Acid:
a) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723416/
b) https://www.cancer.gov/news-events/cancer-currents-blog/2017/zoledronic-acid-bone-metastasis
c) https://www.cancerresearchuk.org/about-cancer/treatment/drugs/zoledronic-acid
5 Common Factors of Individuals with Cancer:
1. Weak Gut Health: Many individuals with cancer have a weakened gut that lacks sufficient acidity and beneficial bacteria. A robust immune system plays a pivotal role in combating cancer cells, and a healthy gut with good bacteria contributes significantly to immune strength. Approximately 85 percent of your immune memory is generated in response to the presence of gut bacteria.
2. Acidic Body pH: Cancer thrives in an acidic environment, typically with pH levels ranging from 5.5 to 6.2. On the contrary, an alkaline body with pH levels between 7.25 and 7.45 is crucial. Extensive research suggests that cancer flourishes in an acidic setting but deteriorates and dies in an alkaline one. Therefore, maintaining an alkaline environment is essential for combating cancer.
3. Low Oxygen Levels: Adequate oxygen supply to your blood cells is essential, as cancer cells can’t live in the presence of high oxygen levels. Unlike healthy cells, cancer cells do not utilize oxygen for their metabolic processes. Ensuring optimal oxygen levels in your bloodstream and cells can help kill cancer growth.
4. Dietary Choices: Individuals who haven't made dietary changes to restrict the nourishment of cancer cells face challenges in combating the disease. Both healthy cells and cancer cells rely on glucose as their primary energy source. While healthy cells can adapt to alternative energy sources like ketone bodies, cancer cells are heavily dependent on glucose. They require substantial energy for growth, which is why they possess about 15 times more insulin receptor sites. Medical professionals use glucose in conjunction with radiological dyes during PET scans to identify cancerous tissues. Adopting a diet that provides essential nutrients while starving cancer cells of glucose is crucial.
5. Overlooking Cancer Stem Cells: Many individuals do not address cancer stem cells effectively, which are the primary reason why cancer returns. Currently, there are no conventional cancer drugs available to target these stem cells. Extensive research suggests that a combination of Doxycycline and high-dose IV Vitamin C disrupt the energy production of cancer stem cells, and converting them into normal cells. Additionally, subst
Creating a Healing Environment: To overcome cancer, it's essential to provide your body with the optimal conditions for healing. This involves maintaining an alkaline pH, bolstering gut health, ensuring proper oxygenation, adopting a cancer-fighting diet, and addressing cancer stem cells through innovative approaches.
CANCER CAN’T LIVE IN AN ALKALINE, OXYGEN RICH ENVIRONMENT
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