Butyrate

Butyrate

Butyrate

Butyrate: The Underestimated Supermolecule in Cancer Management

In the human body's complex ecosystem, even the smallest players can have a profound impact on overall health. A key contributor to this balance is the short-chain fatty acid, butyrate. Emerging as a 'supermolecule,' butyrate has increasingly become a crucial component in the fight against multiple forms of cancer. This article aims to delve into the impressive benefits of butyrate, shedding light on its role as a powerful ally against diseases.

In recent years, the Human Microbiome Project has underscored the pivotal role that our microbiome, the community of microbes living in our body, plays in maintaining our health. Within this community, butyrate-producing bacteria prove essential, constituting a primary defense line against several illnesses, notably cancer.

Butyrate, along with its counterpart’s acetate and propionate, are the main short-chain fatty acids (SCFAs) produced by a healthy microbiome. They emerge from the fermentation of dietary soluble fiber—found in oats, legumes, nuts, seeds, and vegetables—by gut bacteria. Each SCFA has its significance, with butyrate making up approximately 15% of total production in a healthy gut.

There are, in fact, three important SCFAs and their production in the gut varies significantly. In a really healthy gut level are:

  • butyrate (15%),
  • propionate (25%)
  • acetate (65%)

So, what does this supermolecule do? Simply put, butyrate is a multitasking maestro. It fortifies the gut wall, controls intestinal homeostasis, stimulates vitamin D activation, regulates energy metabolism, and even crosses the blood-brain barrier. However, its most potent role is its involvement in cancer management. Research reveals that a lack of butyrate correlates with a heightened cancer risk, with studies linking it to colorectal, breast, lung, prostate, and pancreatic cancer.

For instance, in colorectal cancer, butyrate supports the health of the intestinal mucosa, the gut's innermost lining, and a crucial player in immunity. Multiple studies have shown that butyrate can inhibit colorectal cancer cell proliferation, prompting a reprogramming of cancer cells' metabolism. This fatty acid can suppress and even reduce tumors in the colon when combined with the GPR109A receptor.

In breast and prostate cancer, sodium butyrate has shown promise in triggering apoptosis, or cell death, in cancer cells. Additionally, in pancreatic cancer, butyrate enhances the effectiveness of the drug Gemcitabine, reducing inflammation, preserving intestinal mucosa integrity, and even curtailing lipid metabolism, crucial for cancer metastasis.

The 'gut-lung' axis also illustrates the butyrate-cancer relationship, connecting gut health to lung health. Research from China found significantly lowered levels of butyrate-producing bacteria, including Ruminococcus bromii, in non-small-cell lung cancer (NSCLC) patients.

Despite these promising discoveries, it's crucial to understand that our microbiome's composition is fragile and can be altered by factors like stress, antibiotics, and pathogens, affecting butyrate production. In dysbiosis, a condition where the gut microbiome is imbalanced, one in five adults are affected, leading to a wide range of illnesses, including cancer.

In combating these health challenges, we have found two effective strategies: dietary modification to increase soluble fiber intake and supplementation to ensure adequate butyrate levels. Indeed, supplements containing sodium, potassium, or calcium butyrate or even butyrate-producing bacteria are readily available.

However, butyrate isn't a magic bullet—it's one part of a broader ecosystem that requires balance and care. As ongoing research deepens our understanding of this supermolecule, it becomes clear that nurturing our microbiome, whether through diet, lifestyle, or supplementation, is a powerful tool in supporting our overall health and battling diseases like cancer.

In conclusion, the fascinating story of butyrate—this underestimated supermolecule—emphasizes the importance of the body's ecosystem. It underlines that every part, even those unseen and unheard, plays a vital role in our wellbeing. Our understanding of butyrate, its role, and its potential applications in cancer management are still growing, and may play a crucial role in preventing and fighting cancer. As we gain further insight into this complex ecosystem, we inch closer to the day when we can combat cancer more effectively and efficiently. The journey to discovery is far from over, and butyrate is one potent agent leading the way.

References:

  1. In vitro Fermentation Reveals Changes in Butyrate Production Dependent on Resistant Starch Source and Microbiome Composition; June Teichmann, Darrell W Cockburn; Front Microbiol. 2021 Apr 29;12:640253.
  2. Uptake and metabolism of the short-chain fatty acid butyrate, a critical review of the literature.https://pubmed.ncbi.nlm.nih.gov/22571479/
  3. Butyrate and the colonocyte. In Dietary Fibre in Health and Disease Velázquez, O. C., Lederer, H. M. & Rombeau, J. L. 123–134 (Springer, 1997)
  4. Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and faecal microbiota transplantation. Shen, Z. H. et al; World J. Gastroenterol. 24(1), 5–14 (2018).
  5. Butyrate suppresses the proliferation of colorectal cancer cells via targeting pyruvate kinase M2 and metabolic reprogramming. https://pubmed.ncbi.nlm.nih.gov/29739823/
  6. Characterization of butyrate-metabolism in colorectal cancer to guide clinical treatment; Qinghua Luo, Ping Zhou, Shuangqing Chang, Zhifang Huang & Xuebo Zeng; Scientific Reports volume 13, Article number: 5106 (2023)
  7. Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment; Vahid Salimi et al; Lipids Health Dis. 2017 Nov 2;16(1):208.
  8. Butyrate, a postbiotic of intestinal bacteria, affects pancreatic cancer and gemcitabine response in in vitro and in vivo models; Concetta Panebianco et al; Biomed Pharmacother. 2022 Jul;151:113163.
  9. The association between gut butyrate-producing bacteria and non-small-cell lung cancer; Quifeng Gui et al; J Clin Lab Anal. 2020 Aug;34(8):e23318.
  10. Sodium butyrate regulates androgen receptor expression and cell cycle arrest in human prostate cancer cells; Jeonga Kim et al; Anticancer Res. 2007 Sep-Oct;27(5A):3285-92.
  11. Sodium phenylbutyrate antagonizes prostate cancer through the induction of apoptosis and attenuation of cell viability and migration; Yawen Xu et al; Onco Targets Ther. 2016 May 12;9:2825-33

“Knowing all your treatment options could be life-saving!”

Together, we can beat cancer

Thank you for your interest in the Beat Cancer Foundation. We are here to support you every step of the way in your cancer treatment journey. Please fill out the form below, and our team will be in touch with you shortly. Together, we can beat cancer.